MAC induces mitochondrial fragmentation

Diazepam inhibits cell respiration and induces fragmentation of mitochondrial reticulum.

Diazepam (70-150 micrograms/ml) significantly inhibits oxygen consumption by pig kidney embryo cells and causes the cellular ATP level to fall. The maximum inhibitory effect develops after 1.5-2.5 h of diazepam treatment. In isolated mitochondria diazepam inhibits respiration in state 2 and 3u with glutamate and in state 3u with succinate. Ethylrhodamine staining and electron microscopic study ...

MAC inhibitors suppress mitochondrial apoptosis.

MAC (mitochondrial apoptosis-induced channel) forms in the mitochondrial outer membrane and unleashes cytochrome c to orchestrate the execution of the cell. MAC opening is the commitment step of intrinsic apoptosis. Hence closure of MAC may prevent apoptosis. Compounds that blocked the release of fluorescein from liposomes by recombinant Bax were tested for their ability to directly close MAC a...

Artificially Inducing Close Apposition of Endoplasmic Reticulum and 1 Mitochondria Induces Mitochondrial Fragmentation

Mitochondrial permeability transition increases reactive oxygen species production and induces DNA fragmentation in human spermatozoa.

STUDY QUESTION Does mitochondrial permeability transition (MPT) induced by calcium overload cause reactive oxygen species (ROS) production and DNA fragmentation in human spermatozoa? SUMMARY ANSWER Studies conducted in vitro suggest that in human spermatozoa, MPT occurs in response to intracellular calcium increase and is associated with mitochondrial membrane potential (ΔΨm) dissipation, inc...

Protein kinase C-ε activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules

Nowak G, Bakajsova D, Samarel AM. Protein kinase C-ε activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules. Am J Physiol Renal Physiol 301: F197–F208, 2011. First published February 2, 2011; doi:10.1152/ajprenal.00364.2010.—PKC-ε activation mediates protection from ischemia-reperfusion injury in the myocardium. Mitochondria are a subcellular target of these pr...